Protein Synthesis Inhibitors Flashcards | Quizlet Protein Synthesis Inhibitors Flashcards | Quizlet

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Neostigmine AChE inhibitor or calcium gluconate Neomycin is topical and never parenteral because of nephrotoxicity. Which is the exception? Cephalosporin is another option for these patients.

Demeclocyclin it causes nephrogenic diabetes insipidus How are aminoglycosides administered? Neomycin can be taken orally to kill GI bugs because it won't be absorbed from the GI tract Which drug is the first alternative for someone who is penicillin or Beta-lactam allergic?

Doxycycline it is eliminated via bile Which is the tetracycline of choice for kidney failure patients?

Side-effects[ edit ] A British Medical Journal article highlights that the combination of some macrolides and statins used for lowering cholesterol is not advisable and can lead to debilitating myopathy.

Doxycycline Which generation of tetracyclines name them is part of the triple therapy for H.

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Two other types of acquired resistance rarely seen include the production of drug-inactivating enzymes esterases or kinasesas well as the production of active ATP-dependent efflux proteins that transport the drug outside of the cell.

Which tetracycline is the only one that crosses into the CNS?

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How else might it be administered and why? You discover he was recently prescribed an antibiotic. Ear Ototoxicity A patient on a loop diuretic complains of hearing changes and dizziness. Macrolides are not to be used on non-ruminant herbivores, such as horses and rabbits.

Macrolides, mainly erythromycin and clarithromycin, also have a class effect of QT prolongationwhich can lead to torsades de pointes. Causes tooth pigmentation, enamel hypoplasia, and stunting of growth.

Cholera Rickettsial diseases rocky mountain spotted fever spirochetes It is important to avoid taking tetracyclines with food.

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There is no oral absorption. Unlike penicillin, macrolides have been shown to be effective against Legionella pneumophilamycoplasmamycobacteriasome rickettsiaand chlamydia.

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Uses[ edit ] Antibiotic macrolides are used to treat infections caused by Gram-positive bacteria e. Azithromycin has been used to treat strep throat Group A streptococcal GAS infection caused by Streptococcus pyogenes in penicillin-sensitive patients, however macrolide-resistant strains of GAS are not uncommon.

Tetracyclines are contraindicated in pregnancy, lactation, and in children under 8.

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In infants the use of erythromycin has been associated with pyloric stenosis. Tetracyclines Are tetracyclines broad or narrow spectrum?

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Beta-hemolytic streptococcipneumococcistaphylococciand enterococci are usually susceptible to macrolides.